CA-72.4 (Cancer Antigen 72.4) is a tumor marker primarily used in the detection and monitoring of gastric and ovarian cancers. It plays a role in evaluating treatment effectiveness and disease recurrence. Elevated CA-72.4 levels are often seen in gastrointestinal malignancies, including colorectal and pancreatic cancers. However, it can also be present in non-malignant conditions such as inflammatory diseases and liver disorders. Due to its limited specificity, CA-72.4 is best utilized alongside other biomarkers and imaging studies for accurate disease assessment and monitoring.